secondary polycythemia complications


Secondary polycythemia can be caused by a variety of erythropoietin-producing renal lesions and cancers. Secondary polycythemia is a rare disorder where there are too many red blood cells in your blood. The risk factors for secondary polycythemia (erythrocytosis) are: Polycythemia vera (PV) and essential thrombocythemia (ET) are 2 chronic myeloproliferative diseases (cMPDs) 1 with clinical courses that are characterized by a low rate of transformation into acute myeloid leukemia and myelofibrosis, 2, –4 a long median survival, and an increased risk of venous and arterial thrombosis and of hemorrhage. Cochrane Database Syst Rev. Background: Polycythemia is characterized by rise in hemoglobin and hematocrit, either as a result of hematopoietic clonal expansion (Vera) or secondary to hypoxic stimuli (secondary polycythemia).It is of great importance to detect early and identify the type of polycythemia and also asses the thrombotic risk so that timely and appropriate treatment can be given. [Medline]. It’s rare, but abnormal bone marrow cells grow out of control. What Is Polycythemia Vera? If your spleen is enlarged, you may have symptoms like: If your enlarged spleen causes problems, you may need to take medicine for it, or you may need surgery to remove it. Antithrombotic treatment could prevent such adverse outcome. for: Medscape. Setting: Surgical patients at a university-affiliated Veterans Administration Hospital. Signs of gout include swelling and pain in your joints, especially in your big toe. Schwarcz TH, Hogan LA, Endean ED, et al. 2003 Oct. 123(2):371-2. This is a hormone produced by the kidneys that stimulates the bone marrow cells to produce red blood cells. Genetic causes of erythrocytosis and the oxygen-sensing pathway. AU - Berend, Julia L. PY - 1991/1/1. ", Medscape: "Polycythemia Vera Clinical Presentation," "Polycythemia Vera Treatment & Management. The term polycythemia is used appropriately in the myeloproliferative disorder called polycythemia vera, in which there are elevated levels of all three peripheral blood cell lines—RBCs, white blood cells, and platelets. Patnaik MM, Tefferi A. What people are taking for it . Secondary polycythemia - also called reactive polycythemia - is characterized by excessive production of circulating red blood cells (RBCs) due to hypoxia, tumor, or disease.It occurs in about 2 out of every 100,000 persons who live at or near sea level; incidence increases among people who live at high altitudes. Health conditions that can cause secondary … Control of breathing in patients with chronic obstructive lung diseases and secondary polycythemia after venesection. Complications of treatment include bleeding, especially gastrointestinal haemorrhage and, in particular, variceal ... Ivana Vučinić Ljubičić, Božena Coha, Higher red blood cell distribution width might differentiate primary from secondary polycythemia: A pilot study, International Journal of Laboratory Hematology, 10.1111/ijlh.13373, 0, 0 , (undefined). Enlarged spleen. A case report of strokes in two patients, 42 and 45 years old, with smokers' polycythemia raised the question of whether … These problems don’t happen to everyone who has polycythemia vera. [Full Text]. … Polycythemia is sometimes called erythrocytosis, but the terms are not synonymous, because polycythemia refers to any increase in red blood mass, whereas erythrocytosis only refers to a documented increase of red cell count. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. In the case of high altitude or heart and lung diseases that lead to low blood oxygen content, secondary polycythemia is a physical response that the body makes to improve the oxygen-carrying capacity of the blood. When blood gets thick, it can stick together and form clots inside your veins. Polycythemia is a disease state in which the hematocrit and/or hemoglobin concentration are elevated in peripheral blood. You may also feel fatigued and have dark, tarry stools. Pediatrics. Common symptoms reported by people with secondary polycythemia. Polycythemia vera (PV) and essential thrombocythemia (ET) are 2 chronic myeloproliferative diseases (cMPDs) 1 with clinical courses that are characterized by a low rate of transformation into acute myeloid leukemia and myelofibrosis, 2, –4 a long median survival, and an increased risk of venous and arterial thrombosis and of hemorrhage. [Medline]. Again, these problems aren’t likely. Secondary polycythemia would more accurately be called secondary erythrocytosis or erythrocythemia, as those terms specifically denote increased red blood cells. Symptoms and Complications. DESIGN: Retrospective chart review. Symptoms and Complications. [Medline]. Your spleen is in the upper left part of your abdomen. They are mainly due to the increased thickness (hyperviscosity) and abnormally high numbers of blood cells in the circulating blood. Please confirm that you would like to log out of Medscape. Don’t rub it dry. 296(6):E1319-25. Erslev AJ, Caro J. For a more detailed analysis of Polycythemia as a symptom, including causes, drug side effect causes, and drug interaction causes, please see our Symptom Center information for Polycythemia. Often, this type of polycythemia can be treated by addressing the cause of oxygen shortage. Itching (pruritus) 8. Semin Hematol. They may … and a sense of \"fullness\" in the head and in the left upper abdomen may J Vasc Surg. Jones SD Jr, Dukovac T, Sangkum P, Yafi FA, Hellstrom WJ. Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. Polycythemia vera is a primary bone marrow disorder. If you get an ulcer, you'll likely have stomach pain, along with nausea, vomiting, and a feeling of fullness. Secondary polycythemia is different from polycythemia vera in several ways. PMID: 6758830 DOI: 10.1016/0007-0971(82)90067-5 No abstract available. 2013 Jul-Aug. 19 (4):363-6. Burning sensations of the hands or feet A guideline for the diagnosis and management of polycythaemia vera. This study was performed to know the frequency of secondary polycythemia in patients with COPD. It's caused by the buildup of uric acid in your joints. Secondary polycythemia affects some people as a result of limited oxygen due to smoking or living at high altitudes. 67(5):667-70. Polycythemia vera (also called primary polycythemia) is a rare growth disorder of the bone marrow, occurring when the marrow is overactive and produces more blood cells than the body needs. As a chronic condition, PV needs long-term management. [Full Text]. SETTING: Surgical patients at a university-affiliated Veterans Administration Hospital. Secondary polycythemia. [Medline]. Curr Opin Hematol. [Medline]. Gout is a type of arthritis. 26(7):407-16. Headache 3. If you log out, you will be required to enter your username and password the next time you visit. Ruddy complexion 10. How bad it is. complications. Doctors call this “splenomegaly.”. McMullin MF. Rev Med Interne. Blood. Doctors call this condition myelofibrosis. Secondary polycythemia is caused by excess production of erythropoietin, the hormone that controls red blood cell production. The incidence outside the United States is not well documented but likely to be higher due to the pregnancy complications outlined below that result in fetal/neonatal polycythemia. 23(5):834-44. ", National Heart, Lung, and Blood Institute: "How Is Polycythemia Vera Treated?" Leukemia. Evidence used in this review. [3] Other causes testosterone replacement therapy [4] and heavy cigarette smoking. Am Rev Respir Dis. [Full Text]. [Medline]. Percy MJ, Beard ME, Carter C, Thein SL. Secondary polycythemia results from excess stimulation of erythropoiesis, mainly due to elevated serum levels of erythropoietin.… Secondary Polycythemia: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and … Disease Complications Blood Clots Semin Hematol. It's usually caused by a change in the JAK2 gene, which causes the bone marrow cells to produce too many red blood cells. Its exceptional association with pregnancy can lead to severe complications. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL2Fuc3dlcnMvMjA1MDM5LTc2MTI0L3doYXQtYXJlLWNvbXBsaWNhdGlvbnMtb2Ytc2Vjb25kYXJ5LXBvbHljeXRoZW1pYQ==. Authors B D Harrison, T C Stokes. ", MPN Research Foundation: "What is Primary Myelofibrosis (MF)? 1975 Oct;12(4):353-82. Secondary polycythemia results from excess stimulation of erythropoiesis, mainly due to elevated serum levels of erythropoietin.… Secondary Polycythemia: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and … Increased blood thickness and decreased blood flow, as well as abnormalities in your platelets, increase your risk of blood clots. The potential complications of polycythemia vera can be severe, indeed, which is why it’s so important to obtain treatment early and follow your treatment plan for life. 2011 Dec 9. Nadeem O, Gui J, Ornstein DL. They prevent your blood from clotting the way it should. Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias. [Medline]. 1982 May. Methods: A retrospective review of 143 patients with secondary polycythemia was conducted between December 2003 and March 2017. Sara J Grethlein, MD, FACP Professor of Clinical Medicine, Indiana University School of Medicine; Medical Director of Cancer Services, Indiana University Health, Adult Academic Health Center, IU Simon Cancer and IU North Hospital, Joe and Shelly Schwarz Cancer Center Fatigue 4. Phlebotomy with iron therapy to correct the microcytic polycythemia of chronic hypoxia. J Vasc Surg … The thick, viscous blood causes sluggish circulation, blocks vessels, and interferes with oxygen delivery to the cells that may result in the following symptoms: 1. 1982 May. At extreme levels of secondary polycythemia, patients can be at risk for thrombosis. It’s the clotting of blood in your arteries or veins. Many things can cause itching. Secondary polycythaemia: its causes, effects and treatment. Weakness, headaches, and fatigue are usually the first symptoms of secondary polycythemia. Increased blood thickness and decreased blood flow, as well as abnormalities in your platelets, raise your risk of blood clots. [Full Text]. Polycythemia vera usually produces a high concentration of red blood cells or hemoglobin in the circulating blood, but it's important to note that white blood cell and platelet counts may also be increased. Design: Retrospective chart review. The risk is lower than with primary erythrocytosis but data are too sparse for accurate quantification. Sex Med Rev. 2015 Apr. 49(4):257-62. You may also get medicines like low-dose aspirin, hydroxyurea, or interferon alfa to thin your blood and stop your body from making too many blood cells. 2004 Jul. Blood Rev. Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Received salary from Medscape for employment. Complications of secondary polycythemia are typically related to those of the underlying disease. The disease is often discovered during a routine blood test or physical examination. Renal cysts, hydronephrosis, renal … [Full Text]. At extreme levels of secondary polycythemia, patients can be at risk for thrombosis. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Polycythemia vera is an uncommon condition It occurs more often in men than in women. 2018 Jan. [Medline]. J Pediatr Hematol Oncol. Van Maerken T, Hunninck K, Callewaert L, et al. The JAK-2 mutation is found to be present in over 90% of patients with polycythemia vera. About 3 out of 4 people with PV have an enlarged spleen. J Mol Diagn. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. Liver Cancer: Symptoms, Tests, and Treatments, Understanding Cancer Diagnosis and Treatment, Pain in the upper right part of your belly, Yellow color in your skin and the whites of your eyes, Bleeding in your digestive tract, from the esophagus or gut, A bleeding ulcer or other bleeding in the GI tract. Causes Of Polycythemia. © 2005 - 2019 WebMD LLC. Its symptoms may include: To prevent clots, your doctor will remove a small amount of blood with a treatment called phlebotomy. 3 (2):101-112. The gums and small cuts are likely to bleed, and the hands and feet may burn. Ronald A Sacher, MBBCh, FRCPC, DTM&H Professor of Internal Medicine and Pathology, Director, Hoxworth Blood Center, University of Cincinnati Academic Health Center A blood clot can also form in the main blood vessel that leads to the liver. The secondary polycythemic patients were compared with the matched control group and did not have a higher frequency of these complications. Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management. It could be something else, but you need to find out ASAP. A case report of strokes in two patients, 42 and 45 years old, with smokers' polycythemia raised the question of whether … Blood clots can cause a stroke, a heart attack, or a blockage in an artery in your lungs or a vein deep within a leg muscle or in the abdomen. [Medline]. AU - Lubarsky, David A. One of its main jobs is to recycle old red blood cells. A follow-up study. Prchal JF, Prchal JT. Most of the symptoms of PV occur due to the increased blood viscosity, secondary to increased red blood cell mass. [Medline]. Secondary Polycythemia was found in 26 (10.8%) patients. Signs that your body isn't getting enough oxygen include: PV treatments can improve blood flow and oxygen transport to prevent these symptoms. 125(5):507-10. . Blood carries oxygen around your body. Familial and congenital polycythemias: a diagnostic approach. [Full Text]. Many people have no symptoms when they are first diagnosed with polycythaemia vera. Secondary polycythemia, as the name indicates, occurs secondary to certain underlying causes, which increase the oxygen demand of our body. 2017 Jan. 92 (1):94-108. This can lead to acute myelogenous leukemia, a cancer of the blood and bone marrow. Pillai AA, Babiker HM. Leukemia & Lymphoma Society: "Myelofibrosis Facts. Your doctor may recommend an antihistamine or low-dose aspirin. PV makes the spleen work harder to remove all the extra blood cells. If symptoms do develop, they tend to do so over time. Uric acid forms into hard crystals that leave the joints sore and swollen. Setting: Surgical patients at a university-affiliated Veterans Administration Hospital. Secondary Polycythemia . Secondary polycythemia is caused by factors other than abnormal clone of erythroid proginators. How bad it is. 2008 Dec. 30(6):447-59. They may have: If you take aspirin to prevent clots, it could make the bleeding worse. [Medline]. Typical findings for polycythemia: In many children the only manifestation will be plethora. Passamonti F. How to manage polycythemia vera. 125(5):507-10. Schwarcz TH, Hogan LA, Endean ED, et al. Weakness 2. 2. Possible complications of polycythemia vera include: 1. Balcerzak SP, Bromberg PA. ", National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Questions and Answers About Gout. Common symptom. 90(5):2057-61. Common complications include slower blood flow and development of blood clots. WebMD does not provide medical advice, diagnosis or treatment. Symptoms of secondary polycythemia are the same as those for primary polycythemia and may include: 1. Srikanth Nagalla, MBBS, MS, FACP is a member of the following medical societies: American Society of Hematology, Association of Specialty ProfessorsDisclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Alexion; Alnylam. About complications: Complications of Polycythemia are secondary conditions, symptoms, or other disorders that are caused by Polycythemia. Secondary polycythemia is usually caused by an exposure to low oxygen over an extended amount of time. Complications of Polycythemia Some of the potential complication of polycythemia is increased levels of RBCs circulating in the body which causes increased viscosity or thickness of the blood. Your doctor will closely follow your health to make sure you’re doing well and staying free of complications. 2009 May. Karen Seiter, MD Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College Calverley PM, Leggett RJ, McElderry L, Flenley DC. [Medline]. Secondary polycythemia can be a complication of hypoxic disease, in which oxygen levels in the blood are low, or of genetic mutations or kidney or liver tumors. When PV slows blood flow, it's hard for oxygen to reach your organs. 1986. Secondary polycythemia is limited to overproduction of red cells. Call your doctor or go to an emergency room right away if you have these signs. Secondary Polycythemia. Objective: Secondary polycythemia is an important complication of chronic obstructive pulmonary disease (COPD) but its frequency of occurrence is unknown in our setup. secondary polycythaemia – too many red blood cells are produced as the result of an underlying condition ; Polycythaemia vera (PV) PV is rare. This website also contains material copyrighted by 3rd parties. The complete evaluation of erythrocytosis: congenital and acquired. Molecular basis for polycythemia. 1975 Oct. 12(4):353-82. Carillo S, Henry L, Lippert E, Girodon F, Guiraud I, Richard C, et al. Ip F, di Pierro I, Brown R, et al. Blood clots can cause a stroke, a heart attack or a blockage of an artery in your lungs (pulmonary embolism) or in a vein deep within a muscle (deep vein thrombosis). Platelets normally help your blood clot, but the extra ones in PV don't always work well. [Full Text]. Nested high-resolution melting curve analysis a highly sensitive, reliable, and simple method for detection of JAK2 exon 12 mutations--clinical relevance in the monitoring of polycythemia. "What Are the Signs and Symptoms of Polycythemia Vera? Causes. Red blood cell transfusion requirements for patients with secondary polycythemia were less than that for the matched controls (p < 0.005). Blood clots. Balcerzak SP, Bromberg PA. PMID: 1105791 [Indexed for MEDLINE] Publication Types: It was not known if secondary polycythemia caused by smoking carries the same risk of developing thromboembolic complications as does PV. 13(3):263-70. Polycythemia vera is a rare chronic myeloproliferative disease. [Medline]. Am J Hematol. Read on to find out more about polycythemia, its pathophysiology , primary polycythemia or polycythemia vera , secondary polycythemia , etiology & epidemiology , diagnosis & complications , treatment & prevention & prognosis . Patients may feel lightheaded or experience shortness of breath. CD006503. When this occurs, your blood becomes thick, which makes it difficult for the blood to flow through your smaller blood vessels. This is the same chemical your body releases during an allergic reaction. ", National Organization for Rare Disorders: "Polycythemia Vera. Secondary polycythemia. Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. 1975 Oct;12(4):353-82. Your spleen is in the upper left part of your belly. Possible complications of polycythemia vera include: Blood clots. You get gout when cells turn over too quickly in your body -- like in PV. Sometimes a clot gets loose and travels through a blood vessel. 6(2):100-9. Emmanuel C Besa, MD Professor Emeritus, Department of Medicine, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University Secondary polycythemia. STUDY OBJECTIVE: To determine the effects of secondary polycythemia on perioperative hemorrhagic and thrombotic complications. A headache, dizziness, and fatigue 2. This can happen in different places in your body. Am J Physiol Endocrinol Metab. Sondel PM, Tripp ME, Ganick DJ, Levy JM, Shahidi NT. A rise in histamine levels also causes your stomach to make more acid. Br J Haematol. Secondary polycythemia would more accurately be called secondary erythrocytosis or erythrocythemia, as those terms specifically denote increased red blood cells. Lee FS. Visual disturbances associated with this disorder include distorted vision, blind spots, and flashes of light. The incidence outside the United States is not well documented but likely to be higher due to the pregnancy complications outlined below that result in fetal/neonatal polycythemia. Respiration. Thrombosis is one of the most serious concerns in PV. This rare condition is called Budd-Chiari syndrome. American Association for Cancer Education, American College of Clinical Pharmacology, American Association for the Advancement of Science, American Clinical and Climatological Association, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of Canada. When you have PV, these are about 3 to 5 times more likely than in other people. Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. The disease is often discovered during a routine blood test or physical examination. 2008 Apr 16. This is similar to giving blood during a blood drive. Ronald A Sacher, MBBCh, FRCPC, DTM&H is a member of the following medical societies: American Association for the Advancement of Science, American Association of Blood Banks, American Clinical and Climatological Association, American Society for Clinical Pathology, American Society of Hematology, College of American Pathologists, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of CanadaDisclosure: Nothing to disclose. The risk is lower than with primary erythrocytosis but data are too sparse for accurate quantification. [Medline]. Clin Adv Hematol Oncol. Calverley PM, Leggett RJ, McElderry L, Flenley DC. Esparcieux A, Francina A, Vital-Durand D. [Abnormal haemoglobins with high oxygen affinity in the differential diagnostics of polycythemia]. 1997 Sep 1. Secondary polycythaemia. CCI was used assess CV morbidity burden (low risk ≤4 vs high risk >4). Clinical Spectrum and Complications of Polycythemia, in Patients presenting at Tertiary Care Centre at Goa October 2019 The Journal of the Association of Physicians of India 67(10):20-24 When this occurs, your blood becomes thick, which makes it difficult for the blood to flow through your smaller blood vessels. Remacha AF, Montserrat I, Santamaria A, et al. [Guideline] McMullin MF, Harrison CN, Ali S, Cargo C, Chen F, Ewing J, et al. Histamine makes your skin itch. [Medline]. Int J Lab Hematol. 1997 Jul-Aug. 82(4):406-10. To prevent those problems, your doctor will recommend treatments to improve your blood flow and help you feel better. Erythrocytosis and the Chuvash von Hippel-Lindau mutation. The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era. The goal is to avoid complications like blood clots, which may happen because PV thickens your blood. Deep vein thrombosis (DVT) is a clot in a vein deep inside your leg. 2009 Jun. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. A British Society for Haematology Guideline. Many people have no symptoms when they are first diagnosed with polycythaemia vera. 2008 Nov. 22(6):321-32. Keep the water cool when you shower or take a bath. 1999 Mar. A clot can also lodge in the brain and cause a stroke. Other causes of secondary polycythemia such as chronic hypoxia, chronic kidney disease and obstructive sleep apnea were investigated and determined to not be the cause of polycythemia. [Medline]. Many patients with PV remain asymptomatic for years owing to the extremely slow development of this disease and are found incidentally on routine blood counts revealing increased hemoglobin levels. ", The Myeloproliferative Disorders Research Consortium: "FAQ: About Polycythemia Vera. Polycythemia refers to an absolute increase of red blood cell counts or mass. Haematologica. Secondary polycythemia most often develops as a response to chronic hypoxemia, which triggers increased production of erythropoietin by the kidneys.25 The most common causes of secondary polycythemia include obstructive sleep apnea, obesity hypoventilation syndrome, and chronic obstructive pulmonary disease (COPD). Secondary polycythemia: a boon or a burden? 1. Karen Seiter, MD is a member of the following medical societies: American Association for Cancer Research, American College of Physicians, American Society of HematologyDisclosure: Received honoraria from Novartis for speaking and teaching; Received consulting fee from Novartis for speaking and teaching; Received honoraria from Celgene for speaking and teaching. : about polycythemia vera. `` routine blood test or physical examination to. 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Have no symptoms when they are first diagnosed with polycythaemia vera. `` disease state in which hematocrit... You take aspirin to prevent clots, it can block a blood clot can also form in upper... Blood Institute: `` Questions and Answers about gout often discovered during a blood vessel remove all the red. Rbc-Stimulating hormone called erythropoietin cor pulmonale 11 ( 4.6 secondary polycythemia complications ) while rest 15 ( 6.32 % ).! < 0.005 ). `` rarely seen in people under the age of 40 along with nausea,,... Primary erythrocytosis but data are too sparse for accurate quantification theory should rather... Clinical Presentation, '' `` polycythemia vera an uncommon condition it occurs often... Cancer of the most serious concerns in PV do n't always work well to log out, you will required! Leave sores called peptic ulcers in the heart and cause a heart attack called... Also causes your stomach to make sure you ’ ll want to work with doctor! Which increase the oxygen demand of our body Care: `` FAQ: about polycythemia vera ( ). ’ re doing well and staying free of complications Organization for rare:! Cuts are likely to bleed, and primary myelofibrosis ( MF ) problems, blood! About 3 out of 10 -- have itchy skin response to certain underlying causes, and! Can improve blood flow and help you feel better Research Consortium: `` What are the chemical... The first symptoms of polycythemia: in many children the only manifestation will be plethora the or! And did not have a higher frequency of secondary polycythemia in patients polycythemia! Do develop, they tend to do so over time variety of erythropoietin-producing renal lesions and cancers where underlying! Ganick DJ, Levy JM, Shahidi NT and cause a stroke old red blood cells is polycythemia! Condition it occurs more often in men than in other people the development of blood cells your... To flow through your smaller blood vessels disorder include distorted vision, blind spots, and compromised exercise tolerance smokers... Rise in histamine levels also causes your stomach to make sure you ’ re likely. Stimulates the bone marrow cells grow out of these confirmed secondary polycythemia complications females constitute 11 ( %... & management drugs or hormones treatment of polycythemia can be at risk thrombosis... Times more likely than in other people congenital secondary polycythemia complications for rare Disorders ``... ' polycythemia Guiraud I, Brown R, Indrak K, Stopka,! In secondary polycythemia, patients can be treated by addressing the cause of oxygen shortage LA...

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